Carl M J Kirkpatrick Selected Research

Critical Illness (Critically Ill)

1/2023	Population pharmacokinetics and target attainment analyses to identify a rational empirical dosing strategy for cefepime in critically ill patients.
1/2023	Evaluation of Empirical Dosing Regimens for Meropenem in Intensive Care Unit Patients Using Population Pharmacokinetic Modeling and Target Attainment Analysis.
1/2022	Effect of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against Pseudomonas aeruginosa for the Pharmacokinetics of Critically Ill Patients in a Dynamic Infection Model.
12/2019	Meropenem-Tobramycin Combination Regimens Combat Carbapenem-Resistant Pseudomonas aeruginosa in the Hollow-Fiber Infection Model Simulating Augmented Renal Clearance in Critically Ill Patients.
1/2018	Optimization and Evaluation of Piperacillin-Tobramycin Combination Dosage Regimens against Pseudomonas aeruginosa for Patients with Altered Pharmacokinetics via the Hollow-Fiber Infection Model and Mechanism-Based Modeling.
1/2017	Substantial Impact of Altered Pharmacokinetics in Critically Ill Patients on the Antibacterial Effects of Meropenem Evaluated via the Dynamic Hollow-Fiber Infection Model.
1/2016	Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling.
5/2015	Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients.
2/2015	Are interstitial fluid concentrations of meropenem equivalent to plasma concentrations in critically ill patients receiving continuous renal replacement therapy?
1/2015	Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?

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Carl M J Kirkpatrick Research Topics

Disease

17	Critical Illness (Critically Ill) 01/2023 - 05/2007
12	Infections 10/2022 - 09/2007
8	Body Weight (Weight, Body) 01/2023 - 08/2007
3	Frailty 01/2023 - 01/2016
3	AIDS-Related Complex (ARC) 12/2019 - 01/2016
3	Sepsis (Septicemia) 01/2015 - 07/2009
2	Staphylococcal Infections 12/2021 - 04/2019
2	Neoplasms (Cancer) 01/2018 - 07/2011
2	Inflammation (Inflammations) 12/2014 - 07/2011
2	Obesity 12/2014 - 07/2011
2	Cystic Fibrosis (Mucoviscidosis) 04/2008 - 07/2007
1	Treatment-Resistant Schizophrenia 01/2024
1	Schizophrenia (Dementia Praecox) 01/2023
1	Drug-Related Side Effects and Adverse Reactions 01/2021
1	Chronic Kidney Failure (Chronic Renal Failure) 05/2018
1	Postoperative Pain 01/2018
1	Neoplasm Metastasis (Metastasis) 01/2018
1	Pain (Aches) 01/2018
1	Mania (Manias) 01/2017
1	Bipolar Disorder (Manic Depressive Psychosis) 01/2017
1	Mycoses (Diseases, Fungus) 02/2016
1	Wounds and Injuries (Trauma) 05/2015
1	Cross Infection (Nosocomial Infection) 01/2015
1	Insulin Resistance 12/2014
1	Non-alcoholic Fatty Liver Disease 12/2014
1	Weight Loss (Weight Reduction) 12/2014
1	Abdominal Obesity 12/2014
1	Invasive Candidiasis 11/2014
1	Tuberculosis (Tuberculoses) 02/2013
1	Confusion (Bewilderment) 12/2012
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 07/2012
1	Chronic Disease (Chronic Diseases) 07/2011
1	Acute Kidney Injury (Acute Renal Failure) 09/2010
1	HIV Infections (HIV Infection) 10/2008
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 08/2007
1	Renal Cell Carcinoma (Grawitz Tumor) 08/2007
1	Hypersensitivity (Allergy) 07/2007
1	Hypoalbuminemia 06/2004
1	Heart Failure 10/2002

Drug/Important Bio-Agent (IBA)

7	Piperacillin FDA LinkGeneric 01/2023 - 02/2010
6	Meropenem (Merrem)FDA LinkGeneric 01/2023 - 07/2009
6	CreatinineIBA 01/2023 - 01/2015
5	Anti-Bacterial Agents (Antibiotics)IBA 12/2019 - 07/2007
4	Tobramycin (Nebcin)FDA LinkGeneric 01/2022 - 04/2008
3	Tazobactam FDA LinkGeneric 01/2023 - 02/2010
3	Tazobactam Drug Combination Piperacillin (Zosyn)FDA LinkGeneric 01/2022 - 02/2011
3	Vancomycin FDA LinkGeneric 04/2019 - 01/2012
2	Clozapine (Clozaril)FDA LinkGeneric 01/2024 - 01/2023
2	Cefepime (Maxipime)FDA LinkGeneric 01/2023 - 02/2011
2	Floxacillin (Flucloxacillin)IBA 12/2021 - 09/2007
2	PolyphenolsIBA 12/2014 - 07/2011
2	ResveratrolIBA 12/2014 - 07/2011
1	VaccinesIBA 10/2022
1	Probenecid (Benemid)FDA LinkGeneric 12/2021
1	Carbapenems (Carbapenem Antibiotics)IBA 12/2019
1	Toll-Like Receptor 4IBA 01/2018
1	Opioid Receptors (Opioid Receptor)IBA 01/2018
1	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2018
1	LigandsIBA 01/2018
1	Opioid Analgesics (Opioids)IBA 01/2018
1	Clavulanic Acid (Potassium Clavulanate)FDA LinkGeneric 07/2017
1	AS 8IBA 01/2017
1	LithiumIBA 01/2017
1	5-methoxy-methylindoleacetic acid (DBI)IBA 01/2016
1	Cefazolin (Ancef)FDA LinkGeneric 05/2015
1	Serum AlbuminIBA 05/2015
1	Triglycerides (Triacylglycerol)IBA 12/2014
1	EnzymesIBA 12/2014
1	AntioxidantsIBA 12/2014
1	Anidulafungin FDA Link 11/2014
1	Biomarkers (Surrogate Marker)IBA 02/2013
1	Ofloxacin (Ofloxacine)FDA LinkGeneric 07/2012
1	FluoroquinolonesIBA 07/2012
1	Methicillin (Metin)FDA Link 01/2012
1	ceftobiproleIBA 02/2011
1	Gentamicins (Gentamicin)FDA LinkGeneric 09/2010
1	Fluconazole (Zonal)FDA LinkGeneric 10/2008
1	Insulin-Like PeptidesIBA 08/2007
1	FlavonoidsIBA 08/2007
1	Silybin (Lagosa)IBA 08/2007
1	beta Lactam AntibioticsIBA 07/2007
1	Immunoglobulin E (IgE)IBA 07/2007
1	beta-LactamsIBA 07/2007
1	Cefpirome (HR 810)IBA 05/2007
1	Mycophenolic Acid (Cellcept)FDA LinkGeneric 06/2004
1	UrocortinsIBA 10/2002

Therapy/Procedure

4	Therapeutics 12/2014 - 02/2010
2	Continuous Renal Replacement Therapy 02/2015 - 04/2014
2	Critical Care (Surgical Intensive Care) 02/2010 - 07/2009
1	Polypharmacy 01/2021
1	Drug Therapy (Chemotherapy) 01/2021
1	Replacement Arthroplasty 01/2018
1	Analgesia 01/2018
1	Consolidation Chemotherapy 02/2016
1	Intravenous Infusions 01/2016
1	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2015
1	Medication Errors (Medication Error) 12/2012
1	Intranasal Administration 08/2008